Description

2-{[(1-Acetyl-2,3-Dihydro-1H-Indol-5-Yl)Sulfonyl]Amino}-3-Methylbutanoic Acid is a high-purity, non-natural amino acid derivative featuring a unique indoline sulfonamide scaffold. This compound is a critical advanced pharmaceutical intermediate (API intermediate) valued for its role in constructing complex bioactive molecules. It is primarily sought by pharmaceutical R&D and fine chemical synthesis teams for the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting neurological and metabolic disorders.
• Protease Inhibitor Research: Used in the design and development of enzyme inhibitors due to its sulfonamide and carboxylic acid functional groups.
• Peptidomimetics: Serves as a constrained, non-proteinogenic amino acid analog for creating stable peptide-like structures with enhanced pharmacological properties.
• Chemical Biology Probes: Employed in the creation of molecular probes to study enzyme function and protein-protein interactions.
• Custom Synthesis: Utilized by contract research and manufacturing organizations (CROs/CMOs) for bespoke synthesis projects.
• Academic Research: A valuable reagent for universities and research institutes exploring new synthetic methodologies and bioorganic chemistry.

Basic Information

Product Name	2-{[(1-Acetyl-2,3-Dihydro-1H-Indol-5-Yl)Sulfonyl]Amino}-3-Methylbutanoic Acid
CAS No.	108583-92-2
Molecular Formula	C₁₆H₂₀N₂O₅S
Molecular Weight	352.41 g/mol
Synonyms	2-[[(1-Acetyl-2,3-dihydro-5-indolyl)sulfonyl]amino]-3-methylbutanoic acid; N-[(1-Acetyl-2,3-dihydro-1H-indol-5-yl)sulfonyl]-L-valine; L-Valine, N-[(1-acetyl-2,3-dihydro-5-indolyl)sulfonyl]-; 2-({[1-Acetyl-2,3-dihydro-1H-indol-5-yl]sulfonyl}amino)-3-methylbutanoic acid; 108583-92-2; 1H-Indole-5-sulfonamide, 1-acetyl-2,3-dihydro-N-[(1S)-1-carboxy-2-methylpropyl]-
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch is subjected to comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with customer specifications. We support development projects with GMP-grade material upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.