Description

4-(tert-Butyldimethylsilyloxy)Phenol is a versatile organosilicon-protected phenol derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its primary value lies in the tert-butyldimethylsilyl (TBDMS) protecting group, which offers excellent stability under a wide range of reaction conditions while being selectively removable. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, particularly for the synthesis of complex molecules where selective protection of phenolic hydroxyl groups is required.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for drugs containing phenolic moieties.
• Agrochemical Synthesis: Used in the production of advanced pesticides, herbicides, and plant growth regulators.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of specialty polymers and advanced materials.
• Organic Synthesis Reagent: Employed in multi-step synthetic routes for the protection of phenolic -OH groups in complex natural product and fine chemical synthesis.
• Liquid Crystal & OLED Material Research: Utilized as a starting material for creating functionalized aromatic compounds used in electronic displays.
• Cross-Coupling Reactions: Acts as a substrate in Suzuki, Heck, and other palladium-catalyzed coupling reactions to construct biaryl systems.

Basic Information

Product Name	4-(tert-Butyldimethylsilyloxy)Phenol
CAS No.	108534-47-0
Molecular Formula	C₁₂H₂₀O₂Si
Molecular Weight	224.37 g/mol
Synonyms	4-(tert-Butyldimethylsiloxy)phenol; 4-Hydroxyphenyl tert-butyldimethylsilyl ether; 4-TBDMS-O-Phenol; p-(tert-Butyldimethylsilyloxy)phenol; Phenol, 4-[(1,1-dimethylethyl)dimethylsilyl]oxy]-; 4-OTBDMS Phenol; 4-(Tert-butyldimethylsilyloxy)benzene-1-ol; TBDMS-protected hydroquinone monoether
EINECS	Contact for details

Quality Control

Our 4-(tert-Butyldimethylsilyloxy)Phenol is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with the stringent requirements of our global customer base in research and cGMP manufacturing environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider the use of desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.