Description

Octahydro-Indole-2-Carboxylic Acid tert-Butyl Ester is a protected amino acid derivative that serves as a critical chiral building block in advanced organic synthesis. Its value lies in providing a stereodefined, multifunctional scaffold that is essential for constructing complex molecular architectures with high precision. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), peptidomimetics, and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Peptidomimetics Research: Used to construct constrained peptide analogs and protease inhibitors due to its rigid, bicyclic indoline structure.
• Asymmetric Synthesis: Employed as a starting material or auxiliary in catalytic asymmetric reactions to induce chirality.
• Agrochemical Development: Serves as a building block for novel, high-value crop protection agents and herbicides.
• Academic & Industrial R&D: Utilized in methodological development and the exploration of new chemical spaces in medicinal chemistry.
• Custom Synthesis: A foundational component for contract research organizations (CROs) and CDMOs producing bespoke fine chemicals.

Basic Information

Product Name	Octahydro-Indole-2-Carboxylic Acid tert-Butyl Ester
CAS No.	108395-21-7
Molecular Formula	C₁₃H₂₃NO₂
Molecular Weight	225.33 g/mol
Synonyms	2-tert-Butoxycarbonyloctahydroindole; (2S,3aR,7aS)-1,2,3,3a,4,5,6,7a-Octahydroindole-2-carboxylic acid tert-butyl ester; tert-Butyl octahydro-1H-indole-2-carboxylate; Boc-Octahydroindole-2-carboxylic acid; (3aR,7aS)-2-(tert-Butoxycarbonyl)octahydro-1H-indole; BOC-2-aminoindane-2-carboxylic acid tert-butyl ester (related); Protected 2-aminoindane carboxylic acid derivative.
EINECS	Contact for details

Quality Control

Our Octahydro-Indole-2-Carboxylic Acid tert-Butyl Ester is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.