Description

6-Bromo-1,2,4-triazolo[4,3-a]pyridine is a versatile brominated heterocyclic compound that serves as a critical building block in advanced organic synthesis. Its unique fused triazolopyridine structure, functionalized with a reactive bromine atom, makes it a valuable intermediate for constructing complex molecules with tailored properties. This high-purity intermediate is essential for research and development chemists in the pharmaceutical, agrochemical, and material science industries seeking to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, oncology, and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the research and production of advanced crop protection agents, including herbicides and fungicides, where its heterocyclic core contributes to biological activity.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands used in catalysis and coordination chemistry.
• Material Science Research: Employed in the creation of organic electronic materials, such as charge-transport layers or light-emitting components for OLEDs, due to its electron-deficient aromatic system.
• Chemical Biology Probes: Utilized as a scaffold for developing molecular probes and tags to study biological processes and protein interactions.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Buchwald-Hartwig) to introduce the triazolopyridine moiety into more complex structures.

Basic Information

Product Name	6-Bromo-1,2,4-triazolo[4,3-a]pyridine
CAS No.	108281-79-4
Molecular Formula	C6H4BrN3
Molecular Weight	198.02 g/mol
Synonyms	6-Bromo-[1,2,4]triazolo[4,3-a]pyridine; 6-Bromo-1,2,4-triazolopyridine; 6-Bromo-s-triazolo[4,3-a]pyridine; 6-Bromo-1H-[1,2,4]triazolo[4,3-a]pyridine; 1,2,4-Triazolo[4,3-a]pyridine, 6-bromo-; 108281-79-4 (CAS); 6-Br-TP
EINECS	Contact for details

Quality Control

Our 6-Bromo-1,2,4-triazolo[4,3-a]pyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and scale-up applications. Certificates of Analysis (COA) with detailed batch-specific data are provided to guarantee traceability, consistency, and reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials. The compound is light-sensitive and should be stored away from light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.