Description

4-tert-Butoxycarbonylamino-Thiophene-3-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its unique heterocyclic structure. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs) and novel chemical entities, offering a versatile building block for medicinal chemistry. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly in areas requiring sophisticated thiophene-based scaffolds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel Active Pharmaceutical Ingredients (APIs) and drug candidates.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies for new therapeutic targets.
• Protease Inhibitor Synthesis: Serves as a precursor in the development of protease inhibitor compounds.
• Heterocyclic Compound Library Development: Essential for creating diverse screening libraries in drug discovery programs.
• Custom Synthesis & Contract Manufacturing: Employed in the production of bespoke molecules for clinical and pre-clinical trials.
• Agrochemical Research: Potential intermediate in the development of new crop protection agents.
• Material Science: Investigated as a monomer or precursor for specialty polymers and advanced materials.

Basic Information

Product Name	4-tert-Butoxycarbonylamino-Thiophene-3-Carboxylic Acid
CAS No.	108180-63-8
Molecular Formula	C10H13NO4S
Molecular Weight	243.28 g/mol
Synonyms	4-((tert-Butoxycarbonyl)amino)thiophene-3-carboxylic acid; 4-(Boc-amino)thiophene-3-carboxylic acid; Boc-Thiophene-3-carboxylic Acid Derivative; 3-Carboxy-4-aminothiophene, N-Boc protected; tert-Butyl (3-carboxythiophen-4-yl)carbamate; 4-Aminothiophene-3-carboxylic acid N-Boc derivative; 108180-63-8; 4-(N-Boc-amino)thiophene-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our 4-tert-Butoxycarbonylamino-Thiophene-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.