Description

n-(1,2,2,2-Tetrachloroethoxycarbonyloxy)Succinimide is a specialized chemical reagent primarily used as an active ester intermediate in organic synthesis. Its value lies in its role as a versatile coupling agent for introducing the tetrachloroethoxycarbonyl (Troc) protecting group, which is crucial for the selective protection of amines and alcohols in multi-step synthetic pathways. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly in the synthesis of complex molecules like peptides, nucleotides, and active pharmaceutical ingredients (APIs) where orthogonal protection strategies are required.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for introducing the Troc protecting group in the multi-step synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used as a coupling agent for the temporary protection of amino groups during solid-phase and solution-phase peptide synthesis.
• Nucleotide & Oligonucleotide Production: Employed in the protection of exocyclic amines in nucleosides and nucleotides, facilitating the automated synthesis of DNA/RNA fragments.
• Fine Chemical & Agrochemical Manufacturing: Serves as a building block for creating specialized intermediates used in crop protection agents and performance chemicals.
• Academic & Industrial R&D: A valuable tool for medicinal chemists and process development scientists exploring new synthetic methodologies and protecting group strategies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific projects requiring high-purity synthetic intermediates.

Basic Information

Product Name	n-(1,2,2,2-Tetrachloroethoxycarbonyloxy)Succinimide
CAS No.	107960-02-1
Molecular Formula	C7H5Cl4NO5
Molecular Weight	324.93 g/mol
Synonyms	2,2,2-Trichloroethyl Carbonochloridate Succinimide Ester; Troc-OSu; Troc Succinimide; N-[(2,2,2-Trichloroethoxy)carbonyloxy]succinimide; 2,5-Dioxopyrrolidin-1-yl 2,2,2-trichloroethyl carbonate; Troc-O-Succinimide; N-(Tricloroethoxycarbonyloxy)succinimide; NSC 334906
EINECS	Contact for details

Quality Control

Our n-(1,2,2,2-Tetrachloroethoxycarbonyloxy)Succinimide is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance in cGMP environments for pharmaceutical intermediate manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption, which may affect reactivity. Store away from incompatible materials such as strong bases and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	108 - 112 °C
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.