Description

Ethyl 2-[Bis(2,2,2-Trifluoroethyl)Phosphono] Propionate is a high-value organophosphorus compound featuring a phosphonate ester group flanked by trifluoroethyl moieties. This structure is critical for its role as a versatile building block in advanced organic synthesis, particularly in the preparation of complex molecules with tailored properties. It is essential for R&D and production chemists in the pharmaceutical, agrochemical, and specialty materials industries who require precise, high-purity intermediates for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, especially those targeting enzyme inhibition where the phosphonate group acts as a bioisostere for phosphate.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, pesticides, and plant growth regulators, leveraging the stability and reactivity of the phosphonate ester.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized phosphonate-based ligands used in asymmetric catalysis and metal complexation.
• Material Science Research: Employed in the development of flame retardants, specialty polymers, and surface modifiers where fluorine and phosphorus impart unique characteristics.
• Chemical Biology Probes: Utilized in the design and synthesis of activity-based probes and molecular tools for studying biochemical pathways.

Basic Information

Item	Details
Product Name	Ethyl 2-[Bis(2,2,2-Trifluoroethyl)Phosphono] Propionate
CAS No.	107905-52-2
Molecular Formula	C9H13F6O4P
Molecular Weight	330.16 g/mol
Synonyms	Ethyl 2-(Bis(2,2,2-trifluoroethoxy)phosphoryl)propanoate; Diethyl (2-Ethoxy-2-oxo-1-methylethyl)phosphonate (trifluoroethyl analog); 2-[Bis(2,2,2-trifluoroethyl)phosphono]propionic Acid Ethyl Ester; Phosphonic acid, P-[1-(ethoxycarbonyl)ethyl]-, bis(2,2,2-trifluoroethyl) ester; TFEP Propionate Ester
EINECS	Contact for details

Quality Control

Every batch of Ethyl 2-[Bis(2,2,2-Trifluoroethyl)Phosphono] Propionate is manufactured under strict quality management systems. We provide comprehensive analytical documentation, including Certificates of Analysis (COA) with data from HPLC, NMR (¹H, ¹³C, ³¹P), and GC to verify identity, purity, and consistency. Our quality commitment ensures the material meets the stringent requirements for research and cGMP-grade production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere to maintain stability. Keep away from strong bases and fluorides.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.