Description

4-(5-Fluoro-2-Oxo-2,3-Dihydro-Benzoimidazol-1-Yl)-Piperidine-1-Carboxylic Acid Ethyl Ester is a high-purity, advanced pharmaceutical intermediate critical for modern drug discovery and development. This compound serves as a key building block in the synthesis of complex molecules, offering significant value in creating novel therapeutic agents. It is primarily sought after by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in developing new active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) therapeutic areas.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of novel drug candidates, especially those targeting specific enzyme pathways.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Synthesis: Serves as a core scaffold for constructing complex molecules that become final Active Pharmaceutical Ingredients (APIs).
• Oncology Drug Development: Its benzimidazole-piperidine structure makes it relevant for research into kinase inhibitors and other targeted cancer therapies.
• CNS-Active Compound Research: Applied in the development of potential therapeutics for neurological and psychiatric disorders.
• Custom Synthesis: Supplied to contract research and manufacturing organizations (CROs/CMOs) for custom synthesis projects under cGMP or non-GMP conditions.
• Reference Standard: Can be utilized as a high-purity analytical standard for method development and quality control in pharmaceutical analysis.

Basic Information

Product Name	4-(5-Fluoro-2-Oxo-2,3-Dihydro-Benzoimidazol-1-Yl)-Piperidine-1-Carboxylic Acid Ethyl Ester
CAS No.	107618-33-7
Molecular Formula	C15H16FN3O3
Molecular Weight	305.31 g/mol
Synonyms	Ethyl 4-(5-Fluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidine-1-carboxylate; 1-(1-Ethoxycarbonylpiperidin-4-yl)-5-fluoro-1,3-dihydro-2H-benzimidazol-2-one; 4-(5-Fluoro-2-oxo-1,3-dihydrobenzimidazol-1-yl)piperidine-1-carboxylic acid ethyl ester; 107618-33-7; UNII-9J8V6Y4Q6D; 9J8V6Y4Q6D; SCHEMBL218064; BCP31833; ZINC000006714008.
EINECS	Contact for details

Quality Control

Our 4-(5-Fluoro-2-Oxo-2,3-Dihydro-Benzoimidazol-1-Yl)-Piperidine-1-Carboxylic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets exacting specifications for pharmaceutical research. Certificates of Analysis (COA) detailing all test results are provided with every shipment. We can supply material suitable for research use under standard conditions or tailored to meet specific project requirements, including cGMP-grade intermediates for advanced development phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.