Description

1-Azabicyclo[2.2.2]Octan-3-Ol,3-(Mercaptomethyl)- is a versatile bicyclic tertiary amine derivative featuring both a hydroxyl and a mercaptomethyl functional group, making it a valuable chiral building block and ligand precursor. This compound is critical for the synthesis of complex pharmaceutical intermediates and asymmetric catalysts, where its rigid scaffold and dual functionality enable precise stereochemical control. It is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical sectors for developing new active ingredients and catalytic processes.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the synthesis of novel drug candidates, particularly for neurological and anti-infective agents.
• Catalyst Ligand Precursor: Used to develop chiral ligands for asymmetric synthesis, enabling high enantioselectivity in hydrogenation and other key transformations.
• Agrochemical Research: Employed in the design and synthesis of advanced, stereochemically defined pesticides and herbicides.
• Fine Chemical Synthesis: Acts as a building block for complex natural product analogs and specialty chemicals requiring a rigid bicyclic amine structure.
• Chemical Biology Probe: Utilized in research to create molecular probes that study enzyme mechanisms or protein interactions due to its thiol reactivity.
• Material Science: Investigated as a monomer or cross-linking agent for polymers with specific chelating or catalytic properties.

Basic Information

Product Name	1-Azabicyclo[2.2.2]Octan-3-Ol,3-(Mercaptomethyl)-
CAS No.	107220-26-8
Molecular Formula	C8H15NOS
Molecular Weight	173.28 g/mol
Synonyms	3-(Mercaptomethyl)-3-quinuclidinol; 3-(Mercaptomethyl)quinuclidin-3-ol; 3-Hydroxy-3-mercaptomethylquinuclidine; Quinuclidin-3-ol, 3-(mercaptomethyl)-; 1-Azabicyclo[2.2.2]octan-3-ol, 3-(mercaptomethyl)-; 3-Quinuclidinol, 3-(mercaptomethyl)-
EINECS	Contact for details

Quality Control

Every batch of 1-Azabicyclo[2.2.2]Octan-3-Ol,3-(Mercaptomethyl)- is manufactured and tested under a strict quality management system. We ensure compliance with relevant industry standards for research and pharmaceutical-grade materials. Comprehensive analytical testing, including HPLC for purity and chiral purity assessment, is performed. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment to guarantee traceability and product integrity.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to prevent oxidation. The container should be kept in a cool, dry, and well-ventilated area, separate from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.