Description

Rac-Tenofovir-D7 CAS NO 107021-12-5 is a deuterium-labeled isotopologue of the antiviral nucleotide reverse transcriptase inhibitor, Tenofovir. This stable isotope-labeled compound is a critical tool for quantitative bioanalytical research, enabling precise pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions involved in drug development and analytical method validation.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a high-purity, non-interfering internal standard for the accurate quantification of Tenofovir and its metabolites in biological matrices like plasma, serum, and tissue homogenates.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Essential for conducting mass spectrometry-based assays to determine absorption, distribution, metabolism, and excretion (ADME) profiles of the parent drug.
• Bioanalytical Method Development and Validation: Used as a reference standard to develop, optimize, and validate robust, sensitive, and specific analytical methods compliant with FDA and ICH guidelines.
• Clinical Research and Therapeutic Drug Monitoring (TDM): Enables precise measurement of drug concentrations in patient samples during clinical trials and post-marketing surveillance for HIV and hepatitis B treatments.
• Metabolite Identification and Profiling: Aids in the identification and structural elucidation of Tenofovir metabolites using advanced mass spectrometry techniques.
• Quality Control in Pharmaceutical Manufacturing: Can be employed as a reference material for in-process testing and final product release of Tenofovir-based pharmaceuticals.

Basic Information

Product Name	Rac-Tenofovir-D7
CAS No.	107021-12-5
Molecular Formula	C9H7D7N5O4P
Molecular Weight	290.23 g/mol
Synonyms	Tenofovir-d7; (R)-PMPA-d7; (R)-9-[2-(Phosphonomethoxy)propyl]adenine-d7; (Rac)-Tenofovir-d7; GS 1278-d7; 9-[(R)-2-[(Phosphonomethoxy)propyl]]adenine-d7; PMPA-d7; Bis(POC)PMPA-d7 (pro-drug related)
EINECS	Contact for details

Quality Control

Our Rac-Tenofovir-D7 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for chemical purity, NMR and MS for structural confirmation and isotopic enrichment, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications and test results are provided to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.