Description

p-Methylphosphonic Acid-13C is a stable isotope-labeled analog of methylphosphonic acid, where the methyl carbon is the carbon-13 isotope. This compound is essential for advanced analytical and research applications requiring precise molecular tracking and quantification. It is primarily utilized by researchers and manufacturers in the fields of analytical chemistry, pharmaceutical development, and environmental science for use as an internal standard in mass spectrometry and NMR spectroscopy.

Application

• Internal Standard for Mass Spectrometry (MS): Provides accurate quantification in LC-MS and GC-MS analysis of phosphonic acids and related compounds.
• NMR Spectroscopy Tracer: Used in metabolic pathway studies and reaction mechanism elucidation due to the distinct carbon-13 signal.
• Pharmaceutical Research: Employed in the development and validation of analytical methods for drug substances and metabolites containing phosphonate groups.
• Environmental Analysis: Aids in the sensitive detection and monitoring of organophosphorus compounds in complex matrices.
• Chemical Synthesis Intermediate: Serves as a labeled building block for the synthesis of more complex isotopically labeled molecules.
• Forensic and Defense Research: Used in method development for the detection of specific chemical agents and their degradation products.

Basic Information

Product Name	p-Methylphosphonic Acid-13C
CAS No.	106976-96-9
Molecular Formula	CH313COOH
Molecular Weight	112.01 g/mol (for 13C labeled form)
Synonyms	Methylphosphonic Acid-13C; (Methyl-13C)phosphonic Acid; 13C-Labeled Methylphosphonic Acid; Phosphonomethyl-13C Acid; MPA-13C; Methyl-13C-phosphonic Acid; 1-13C-Methylphosphonic Acid
EINECS	Contact for details

Quality Control

Our p-Methylphosphonic Acid-13C is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high isotopic purity and chemical purity, critical for its role as a quantitative standard. Certificates of Analysis (COA) detailing isotopic enrichment, assay, and impurity profiles by techniques such as NMR and HPLC are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isotopic Purity (13C)	≥ 99 atom % 13C
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.