Description

(6As)-8α-Chloro-9β-Ethenyl-6,6Aβ,7,8,9,10-Hexahydro-10β-Isocyano-6,6,9-Trimethylnaphth[1,2,3-Cd]Indol-10Aα(2H)-Ol is a complex, high-value synthetic organic compound featuring a fused polycyclic structure with chloro, ethenyl, and isocyano functional groups. This compound serves as a critical advanced pharmaceutical intermediate or key building block in sophisticated organic syntheses, particularly for research into novel bioactive molecules. It is primarily sought by pharmaceutical R&D and fine chemical synthesis teams for developing new therapeutic agents and complex natural product analogs.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel alkaloid-based drug candidates targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used as a sophisticated scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Organic Synthesis Building Block: Employed in complex multi-step syntheses, leveraging its reactive isocyano and chloro groups for further functionalization.
• Natural Product Analog Synthesis: Serves as a core structure for synthesizing analogs of complex indole or naphthindole-based natural products.
• Chemical Biology Probes: Potential use in developing activity-based probes or labeled compounds for biochemical and pharmacological research.
• Process Chemistry Development: Used in route scouting and optimization for the scalable production of target active pharmaceutical ingredients (APIs).

Basic Information

Product Name	(6As)-8α-Chloro-9β-Ethenyl-6,6Aβ,7,8,9,10-Hexahydro-10β-Isocyano-6,6,9-Trimethylnaphth[1,2,3-Cd]Indol-10Aα(2H)-Ol
CAS No.	106865-68-3
Molecular Formula	C22H25ClN2O
Molecular Weight	368.90 g/mol
Synonyms	8α-Chloro-9β-ethenyl-6,6aβ,7,8,9,10-hexahydro-10β-isocyano-6,6,9-trimethylnaphth[1,2,3-cd]indol-10aα(2H)-ol; (6aS,9R,10R,10aR)-8-Chloro-9-ethenyl-6,6a,7,8,9,10-hexahydro-10-isocyano-6,6,9-trimethyl-4H-naphtho[1,2,3-cd]indol-10a(2H)-ol; NSC 339586; Complex Indole Isonitrile Derivative; Chloro-Ethenyl-Trimethylnaphthindole Isonitrile
EINECS	Contact for details

Quality Control

Our production of (6As)-8α-Chloro-9β-Ethenyl-6,6Aβ,7,8,9,10-Hexahydro-10β-Isocyano-6,6,9-Trimethylnaphth[1,2,3-Cd]Indol-10Aα(2H)-Ol adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. Quality is verified against established in-house specifications using advanced analytical techniques. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed under an inert atmosphere if necessary to ensure long-term stability. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single unknown impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.