Description

1-Azabicyclo[2.2.2]Octane, 2-Ethynyl- (9Ci) is a specialized bicyclic tertiary amine building block featuring a reactive ethynyl group. This compound is valued for its unique structural framework, which serves as a key precursor in advanced organic synthesis and pharmaceutical research. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing complex nitrogen-containing molecular architectures.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in developing central nervous system (CNS) and neurological disorder therapeutics.
• Ligand Synthesis: Used in the preparation of sophisticated ligands for catalysis and metal-organic frameworks (MOFs) due to its rigid bicyclic structure and coordinating nitrogen atom.
• Agrochemical Research: Serves as a key intermediate in the development of new crop protection agents and herbicides with novel modes of action.
• Material Science: Employed in the synthesis of advanced polymers and functional materials where the ethynyl group enables further cross-linking or modification.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic chemistry, including click chemistry and palladium-catalyzed cross-coupling reactions.

Basic Information

Product Name	1-Azabicyclo[2.2.2]Octane, 2-Ethynyl- (9Ci)
CAS No.	106824-77-5
Molecular Formula	C9H13N
Molecular Weight	135.21 g/mol
Synonyms	2-Ethynyl-1-azabicyclo[2.2.2]octane; 2-Ethynylquinuclidine; Quinuclidine, 2-ethynyl-; 2-Ethynylquinuclidine; 1-Azabicyclo[2.2.2]octane, 2-ethynyl-; 2-Ethynyl-1-azoniabicyclo[2.2.2]octane (cationic form reference); 106824-77-5 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Our 1-Azabicyclo[2.2.2]Octane, 2-Ethynyl- (9Ci) is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and impurity profiles. We support cGMP and ISO 9001 standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in its original sealed packaging to prevent degradation. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.