Description

6-(tert-Butyldimethylsilyloxy)-Indole is a key protected indole derivative, specifically designed as a versatile synthetic intermediate for advanced organic synthesis. Its primary value lies in providing a robust, silyl-protected hydroxyl group that is stable to a wide range of reaction conditions, enabling precise and complex molecular construction. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and fine chemical industries, particularly for the development of novel active ingredients and complex natural product analogs.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of complex drug candidates, especially those containing indole or tryptamine scaffolds.
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides that require functionalized indole structures.
• Fine Chemical Production: Serves as a precursor for specialty chemicals, dyes, and advanced materials.
• Academic & R&D: A valuable reagent in medicinal chemistry and organic methodology research for exploring new synthetic pathways.
• Peptide Mimetics: Employed in the construction of non-natural amino acids and peptide analogs with enhanced stability.
• Natural Product Synthesis: Facilitates the total synthesis of complex indole alkaloids found in nature.

Basic Information

Product Name	6-(tert-Butyldimethylsilyloxy)-Indole
CAS No.	106792-41-0
Molecular Formula	C14H21NOSi
Molecular Weight	247.41 g/mol
Synonyms	6-[(tert-Butyldimethylsilyl)oxy]-1H-indole; 6-(TBDMSO)-Indole; 6-Hydroxyindole tert-butyldimethylsilyl ether; 6-O-TBDMS-indole; 1H-Indol-6-ol, 1-(1,1-dimethylethyl)dimethylsilyl ether; 6-(tert-Butyldimethylsiloxy)indole; 6-TBDMS-Oxyindole
EINECS	Contact for details

Quality Control

Our 6-(tert-Butyldimethylsilyloxy)-Indole is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for demanding R&D and scale-up processes. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. While typically supplied as a high-purity research chemical, specifications can be aligned with cGMP standards for advanced pharmaceutical development upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.