Description

5-(tert-Butyldimethylsilyloxy)-1H-Indole is a protected indole derivative, a crucial synthetic intermediate in advanced organic chemistry. This compound is valued for its role in constructing complex molecular architectures, particularly in pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of novel active compounds.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug candidates, particularly those containing indole or tryptamine scaffolds.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides that require functionalized indole structures.
• Fine Chemical Production: Serves as a versatile precursor for creating specialty chemicals, dyes, and advanced materials.
• Academic & Industrial R&D: Essential reagent in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Peptidomimetic Synthesis: Employed in the construction of peptide analogs and other biologically active molecules.
• Alkaloid Synthesis: A critical starting material or intermediate in the total synthesis of natural products and alkaloids.

Basic Information

Product Name	5-(tert-Butyldimethylsilyloxy)-1H-Indole
CAS No.	106792-38-5
Molecular Formula	C14H21NOSi
Molecular Weight	247.41 g/mol
Synonyms	5-[(tert-Butyldimethylsilyl)oxy]-1H-indole; 5-(TBDMSO)-1H-Indole; 5-Hydroxy-1H-indole, TBDMS ether; 1H-Indol-5-ol, 1-[(1,1-dimethylethyl)dimethylsilyl] ether; 5-O-TBDMS-indole; 5-tert-Butyldimethylsilyloxyindole; 5-(tert-Butyldimethylsiloxy)indole; 5-TBDMS-Oxyindole
EINECS	Contact for details

Quality Control

Our 5-(tert-Butyldimethylsilyloxy)-1H-Indole is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research and scale-up applications. All products undergo rigorous analytical testing, including HPLC, NMR, and GC-MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids, bases, and oxidizing agents. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon to maximize stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Melting Point	Contact for details
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.