Description

5-Thiazolecarboxylic Acid, 4-(Trifluoromethyl)-, Ethyl Ester is a high-value trifluoromethyl-substituted thiazole derivative, serving as a critical building block in advanced organic synthesis. This compound is prized for its ability to introduce the metabolically stable and lipophilic trifluoromethyl group into target molecules, significantly altering their physicochemical and biological properties. It is an essential intermediate for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and anti-inflammatory drug discovery programs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the CF3 group enhances bioactivity and environmental stability.
• Material Science Research: Serves as a precursor for functionalized heterocycles used in organic electronics, liquid crystals, and advanced polymer materials.
• Chemical Biology & Proteomics: Employed as a building block for designing chemical probes and activity-based protein profiling (ABPP) agents.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis services catering to R&D and pilot-scale production needs.

Basic Information

Product Name	5-Thiazolecarboxylic Acid, 4-(Trifluoromethyl)-, Ethyl Ester
CAS No.	106203-24-1
Molecular Formula	C7H6F3NO2S
Molecular Weight	225.19 g/mol
Synonyms	Ethyl 4-(Trifluoromethyl)thiazole-5-carboxylate; 4-(Trifluoromethyl)-1,3-thiazole-5-carboxylic Acid Ethyl Ester; 5-Thiazolecarboxylic acid, 4-(trifluoromethyl)-, ethyl ester; 4-Trifluoromethyl-thiazole-5-carboxylic acid ethyl ester; 4-CF3-Thiazole-5-carboxylic acid ethyl ester; 4-(Trifluoromethyl)-5-thiazolecarboxylic acid ethyl ester; 5-Carbethoxy-4-trifluoromethylthiazole
EINECS	Contact for details

Quality Control

Our production of 5-Thiazolecarboxylic Acid, 4-(Trifluoromethyl)-, Ethyl Ester adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality system supports development under cGMP guidelines for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Standard Grade)
Purity (GC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.