Description

3 α-Hydroxy-6-Fluoroindoline is a fluorinated indoline derivative, a key chiral building block in modern organic synthesis. Its value lies in the strategic combination of a reactive hydroxyl group and a fluorine atom on the indoline scaffold, enabling precise molecular modifications. This compound is essential for research chemists and process development teams in the pharmaceutical and agrochemical industries, particularly for the synthesis of complex bioactive molecules and advanced intermediates.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the development of novel active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the fluorine atom enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Investigated as a monomer or functional additive for developing novel fluorinated polymers with specific optical or electronic properties.
• Chemical Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling.
• Academic & R&D: A valuable tool for methodological studies in organic chemistry, including novel fluorination and cyclization reactions.

Basic Information

Product Name	3 α-Hydroxy-6-Fluoroindoline
CAS No.	106072-73-5
Molecular Formula	C8H8FNO
Molecular Weight	153.15 g/mol
Synonyms	3α-Hydroxy-6-fluoroindoline; 6-Fluoro-3-hydroxyindoline; (3R)-6-Fluoro-2,3-dihydro-1H-indol-3-ol (enantiomer); 6-Fluoroindolin-3-ol; 1H-Indol-3-ol, 6-fluoro-2,3-dihydro-; 3-Hydroxy-6-fluoroindoline; (R)-6-Fluoro-2,3-dihydro-1H-indol-3-ol
EINECS	Contact for details

Quality Control

Every batch of 3 α-Hydroxy-6-Fluoroindoline is manufactured under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency, supporting your regulatory and process requirements. A detailed Certificate of Analysis (COA) including chiral purity (enantiomeric excess) is supplied with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.