Description

D-[1-2H]Glucose is a stable isotope-labeled analog of D-glucose, specifically deuterated at the 1-position. This high-purity labeled compound is essential for advanced research requiring precise metabolic tracing and quantification. It is a critical tool for scientists in pharmaceutical development, metabolic research, and analytical chemistry who require reliable, isotopically pure materials for mass spectrometry and NMR studies.

Application

• Metabolic Pathway Tracing: Used as a stable isotope tracer in in vitro and in vivo studies to elucidate glucose metabolism, glycolysis, and the pentose phosphate pathway.
• Quantitative Mass Spectrometry (MS): Serves as an internal standard for the accurate quantification of endogenous glucose and its metabolites in complex biological matrices like plasma, serum, and cell lysates.
• Nuclear Magnetic Resonance (NMR) Spectroscopy: Employed in mechanistic studies to investigate enzyme kinetics and metabolic fluxes without radioactive hazards.
• Pharmaceutical Research & Development: Utilized in drug metabolism and pharmacokinetics (DMPK) studies to track the metabolic fate of new chemical entities.
• Clinical Diagnostics Research: Applied in developing and validating assays for metabolic disorders such as diabetes.
• Biochemical Research: Used in enzymatic assays and studies of carbohydrate-active enzymes.

Basic Information

Product Name	D-[1-2H]Glucose
CAS No.	106032-61-5
Molecular Formula	C6H11DO6
Molecular Weight	181.16 g/mol
Synonyms	1-Deuterio-D-glucose; D-Glucose-1-d; Deuterated D-glucose; (2R,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal-1-d; 1-Deutero-D-glucose; D-Glucose (1-2H); [1-2H]-D-Glucose; Stable Isotope Labeled D-Glucose
EINECS	Contact for details

Quality Control

Our D-[1-2H]Glucose is manufactured under controlled conditions to ensure exceptional isotopic and chemical purity, meeting the stringent requirements of research and analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (Atom % 2H), chemical purity, and specific optical rotation. We adhere to rigorous internal quality standards to guarantee batch-to-batch consistency and reliability for your critical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isotopic Enrichment (Atom % 2H)	≥ 98.0%
Specific Optical Rotation	+52.5° to +53.0° (c=10, H2O)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.