Description

L-Serine (2,3,3-D3) is a stable isotope-labeled analog of the essential amino acid L-serine, specifically deuterated at the 2, 3, and 3 positions. This high-purity compound is critical for advanced research and development where precise metabolic tracing and structural elucidation are required. It is primarily utilized by scientists and manufacturers in the pharmaceutical, biotechnology, and analytical chemistry sectors for applications such as mass spectrometry, NMR spectroscopy, and the development of labeled pharmaceuticals.

Application

• Internal Standard for Mass Spectrometry (MS): Used as a quantitative reference in LC-MS and GC-MS analyses for accurate measurement of endogenous L-serine levels in complex biological matrices.
• Metabolic Pathway Tracing: Enables detailed study of serine metabolism, glycine synthesis, and one-carbon unit cycles in cell culture, animal models, and clinical research.
• NMR Spectroscopy Studies: Serves as a valuable probe for protein structure, dynamics, and interaction studies due to the distinct magnetic properties of deuterium.
• Pharmaceutical Research & Development: Employed in the synthesis of deuterated drug candidates to potentially improve pharmacokinetic profiles, a process known as the deuterium switch.
• Biochemical Assay Development: Used in the creation of calibrated assays and diagnostic kits requiring high-specificity labeled compounds.
• Stable Isotope Labeling in Cell Culture (SILAC): Facilitates quantitative proteomics by enabling the incorporation of heavy labels into proteins for comparative analysis.

Basic Information

Product Name	L-Serine (2,3,3-D3)
CAS No.	105591-10-4
Molecular Formula	C3H4D3NO3
Molecular Weight	108.11 g/mol
Synonyms	(2S)-2-Amino-3,3,3-trideuterio-2-hydroxypropanoic Acid; L-Serine-d3; (S)-Serine-d3; Serine-2,3,3-d3; Deuterated L-Serine; L-2-Amino-3,3,3-trideuterio-2-hydroxypropanoic Acid; (S)-2-Amino-3,3,3-trideuteriopropanoic Acid
EINECS	Contact for details

Quality Control

Our L-Serine (2,3,3-D3) is manufactured under strict quality systems to ensure exceptional isotopic and chemical purity, meeting the rigorous demands of research and regulatory applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic purity (atom % D), chemical purity (by HPLC), chiral purity, and residual solvent content. We adhere to relevant standards for high-purity biochemicals, and custom specifications or cGMP-grade material can be discussed based on project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation due to moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Atom % D)	≥ 98.0% (by MS)
Chiral Purity ([α]D)	≥ 99.0% L-Isomer
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.