Description

3-Thiophenecarbonitrile, 2-Amino-4-Hydroxy-5-Methyl- is a high-purity, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its unique molecular structure, featuring amino, hydroxy, and nitrile groups on a thiophene core, makes it a versatile precursor for creating complex molecules with tailored properties. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Serves as a crucial building block for creating advanced pesticides, herbicides, and fungicides with improved efficacy and environmental profiles.
• Material Science Research: Used in the synthesis of functional polymers, organic semiconductors, and conductive materials due to the electron-rich thiophene moiety.
• Ligand and Catalyst Development: The amino and hydroxy groups make it a suitable precursor for designing novel chelating ligands and organocatalysts.
• Dye and Pigment Chemistry: Acts as an intermediate in the synthesis of specialized dyes and pigments for high-performance applications.
• Academic & Industrial R&D: A valuable reagent for methodological studies in heterocyclic chemistry and the exploration of new chemical spaces.

Basic Information

Product Name	3-Thiophenecarbonitrile, 2-Amino-4-Hydroxy-5-Methyl-
CAS No.	105558-73-4
Molecular Formula	C6H6N2OS
Molecular Weight	154.19 g/mol
Synonyms	2-Amino-4-hydroxy-5-methylthiophene-3-carbonitrile; 5-Methyl-2-amino-4-hydroxythiophene-3-carbonitrile; 4-Hydroxy-5-methyl-2-aminothiophene-3-carbonitrile; 2-Amino-4-hydroxy-5-methyl-3-thiophenecarbonitrile; 3-Cyano-2-amino-4-hydroxy-5-methylthiophene; 5-Methyl-4-hydroxy-2-aminothiophene-3-carbonitrile; AHMT-CN (common abbreviation); 3-Thiophenecarbonitrile, 2-amino-4-hydroxy-5-methyl-
EINECS	Contact for details

Quality Control

Our 3-Thiophenecarbonitrile, 2-Amino-4-Hydroxy-5-Methyl- is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and scale-up. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as identity, assay, and impurity profiles. For projects requiring specific grade qualifications (e.g., pharmaceutical development), we offer material produced under cGMP guidelines and can support regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider the use of desiccants.

Specification

Item	Specification
Appearance	Yellow to brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.