Description

N,o-Bis(Diethylhydrogensilyl)Trifluoroacetamide is a specialized organosilicon reagent primarily used as a powerful silylating agent for analytical chemistry and organic synthesis. This compound matters for its ability to efficiently derivatize a wide range of polar, labile compounds, enhancing their volatility and thermal stability for precise analysis. It is critically needed by analytical laboratories and R&D chemists in the pharmaceutical, agrochemical, and material science industries for gas chromatography (GC) and mass spectrometry (MS) applications.

Application

• Derivatization Reagent for GC/MS Analysis: Used to silylate hydroxyl, carboxyl, and amine groups in complex organic molecules, steroids, and drug metabolites to improve their chromatographic properties.
• Protecting Group in Organic Synthesis: Serves as a versatile protecting agent for sensitive functional groups during multi-step synthetic sequences, particularly in pharmaceutical intermediate manufacturing.
• Surface Modification Agent: Applied in material science to modify the surface properties of silica, glass, or other oxides, imparting specific hydrophobic or reactive characteristics.
• Reagent for Silyl Enol Ether Formation: Facilitates the preparation of silyl enol ethers from ketones, which are key intermediates in aldol and other carbon-carbon bond-forming reactions.
• Cross-Coupling and Catalysis: May be employed as a precursor or ligand in the development of novel silicon-containing catalysts for cross-coupling reactions.

Basic Information

Product Name	N,o-Bis(Diethylhydrogensilyl)Trifluoroacetamide
CAS No.	105384-38-1
Molecular Formula	C10H22F3NOSi2
Molecular Weight	285.45 g/mol
Synonyms	Bis(diethylsilyl)trifluoroacetamide; BSTFA with 1% TMCS (common formulation); N,O-Bis(diethylhydrogensilyl)trifluoroacetamide; Diethylsilyl Trifluoroacetamide Reagent; Silylating Agent BSTFA (Diethyl); 1,1,1-Trifluoro-N-(diethylhydrogensilyloxy)-N-(diethylsilyl)methanimine; TFA Diethylsilyl Ester
EINECS	Contact for details

Quality Control

Our N,o-Bis(Diethylhydrogensilyl)Trifluoroacetamide is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for sensitive analytical and synthetic work. Each lot is tested via GC, NMR, and Karl Fischer titration to confirm identity, purity, and moisture content. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at temperatures between 2°C and 8°C (refrigerated) to minimize volatility and degradation. Due to its hygroscopic and highly volatile nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) when not in use and allowed to equilibrate to room temperature before opening to prevent moisture ingress.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Refractive Index (n20D)	1.390 - 1.400
Density (20°C)	1.00 - 1.10 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.