Description

(Benzotriazol-1-Yloxy)Dipyrrolidinocarbenium Hexafluorophosphate is a highly reactive peptide coupling reagent, commonly known as PyBOP, belonging to the class of benzotriazol-1-yl-oxytris(dimethylamino)phosphonium salts. It is a critical reagent for facilitating amide bond formation in peptide synthesis, offering advantages in minimizing racemization and providing high coupling efficiency. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries engaged in solid-phase and solution-phase peptide synthesis.

Application

• Peptide Synthesis: Primary reagent for the formation of amide bonds in both solid-phase and solution-phase peptide synthesis.
• Pharmaceutical Intermediate Production: Used in the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs) requiring peptide linkages.
• Bioconjugation: Facilitates the coupling of peptides to other molecules, such as proteins, polymers, or labels, for creating bioconjugates.
• Combinatorial Chemistry: Employed in high-throughput synthesis for generating libraries of peptide-based compounds for drug discovery.
• Macrocyclization: Applied in the synthesis of cyclic peptides, which are important for their enhanced stability and biological activity.
• Segment Condensation: Used in the condensation of protected peptide fragments to construct longer peptide chains.

Basic Information

Product Name	(Benzotriazol-1-Yloxy)Dipyrrolidinocarbenium Hexafluorophosphate
CAS No.	105379-24-6
Molecular Formula	C18H28F6N6OP
Molecular Weight	520.43 g/mol
Synonyms	PyBOP; Benzotriazol-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate; (1H-Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate; BOP Reagent Analog; Coupling Reagent PyBOP; Hexafluorophosphate (1H-benzotriazol-1-yloxy)tripyrrolidinophosphonium; CAS 105379-24-6
EINECS	Contact for details

Quality Control

Our (Benzotriazol-1-Yloxy)Dipyrrolidinocarbenium Hexafluorophosphate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistent performance as a peptide coupling reagent. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and assay is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under a dry, inert atmosphere to prevent decomposition. Keep away from strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.