Description

(4R)-1,2,3,4-Tetrahydroisoquinolin-4-Ol CAS NO 105181-85-9 is a chiral, non-racemic tetrahydroisoquinoline derivative, a privileged scaffold in medicinal chemistry. This compound serves as a critical chiral building block and intermediate for the synthesis of more complex, biologically active molecules. It is primarily needed by pharmaceutical R&D and fine chemical synthesis teams developing new drug candidates, particularly in the areas of central nervous system (CNS) agents and alkaloid-based therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of potential drug candidates targeting neurological disorders.
• Asymmetric Synthesis: Used as a chiral auxiliary or starting material in stereoselective chemical reactions to introduce the (4R) configuration.
• Alkaloid Research: Serves as a core structural unit for the preparation of tetrahydroisoquinoline alkaloids and their analogs for biological screening.
• Ligand & Catalyst Development: Employed in the research and development of novel chiral ligands for catalytic asymmetric transformations.
• Chemical Reference Standard: Used as a high-purity standard in analytical method development and quality control for related compounds.
• Academic & Industrial R&D: Fundamental research tool in organic chemistry and medicinal chemistry laboratories for exploring new synthetic pathways.

Basic Information

Item	Details
Product Name	(4R)-1,2,3,4-Tetrahydroisoquinolin-4-Ol
CAS No.	105181-85-9
Molecular Formula	C9H11NO
Molecular Weight	149.19 g/mol
Synonyms	(4R)-1,2,3,4-Tetrahydro-4-hydroxyisoquinoline; (R)-1,2,3,4-Tetrahydroisoquinolin-4-ol; (R)-4-Hydroxy-1,2,3,4-tetrahydroisoquinoline; (R)-THIQ-4-ol; (R)-4-Hydroxy-THIQ; (4R)-4-Hydroxy-1,2,3,4-tetrahydroisoquinoline; (R)-1,2,3,4-Tetrahydro-4-isoquinolinol
EINECS	Contact for details

Quality Control

Our (4R)-1,2,3,4-Tetrahydroisoquinolin-4-Ol is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and fine chemical synthesis. Certificates of Analysis (COA) detailing identity, purity, and chiral excess are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.