Description

4-Thiazolecarboxylicacid,4,5-Dihydro-,Methylester,(4R)-(9Ci) is a high-purity chiral building block and synthetic intermediate of significant value in advanced organic synthesis. Its defined stereochemistry and functionalized thiazoline core make it a critical precursor for the development of novel pharmaceuticals and bioactive compounds. This product is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to incorporate stereochemically defined heterocyclic motifs into their target molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing thiazoline or related heterocyclic structures.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides where specific stereochemistry influences biological activity.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands used in asymmetric catalysis, enabling enantioselective synthetic transformations.
• Peptidomimetics and Bioactive Molecule Synthesis: Incorporated into complex molecules designed to mimic peptide structures or interact with biological targets.
• Chemical Biology Probes: Utilized in the construction of molecular probes for studying enzyme mechanisms or protein interactions.
• Fine Chemical and Specialty Material Production: Employed in the multistep synthesis of complex, high-value specialty chemicals for various industrial applications.

Basic Information

Product Name	4-Thiazolecarboxylicacid,4,5-Dihydro-,Methylester,(4R)-(9Ci)
CAS No.	105118-41-0
Molecular Formula	C5H7NO2S
Molecular Weight	145.18 g/mol
Synonyms	(4R)-4,5-Dihydro-4-thiazolecarboxylic acid methyl ester; Methyl (4R)-4,5-dihydro-1,3-thiazole-4-carboxylate; (R)-Methyl 4,5-dihydrothiazole-4-carboxylate; (R)-4,5-Dihydrothiazole-4-carboxylic acid methyl ester; (4R)-4,5-Dihydro-δ⁴-thiazoline-4-carboxylic acid methyl ester; (R)-Thiazoline-4-carboxylic acid methyl ester; (R)-Methyl 2,3-dihydro-1,3-thiazole-4-carboxylate
EINECS	Contact for details

Quality Control

Our production of this chiral intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and high chemical purity. Every lot is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chiral purity (enantiomeric excess), chemical purity, and identity confirmation. We employ advanced analytical techniques including HPLC, GC, and chiral chromatography to meet the exacting standards required for pharmaceutical R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	White to off-white solid or clear to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.