Description

17Alpha-Hydroxypregnenolone-21,21,21-D3 is a high-purity, deuterium-labeled steroid derivative, specifically designed for use as a critical reference standard and metabolic tracer. This compound matters for its role in enabling precise analytical quantification and metabolic pathway studies in pharmaceutical and clinical research. It is primarily needed by research scientists and quality control laboratories in the pharmaceutical, biotechnology, and diagnostic sectors for applications in method development, validation, and advanced LC-MS/MS analysis.

Application

• Pharmaceutical Reference Standard: Used as a certified internal standard for the accurate quantification of related steroids and metabolites in drug development and bioanalytical assays.
• Metabolic Tracer Studies: Employed in research to investigate steroidogenesis pathways, enzyme activity, and drug metabolism due to its stable deuterium labels.
• Clinical Diagnostics: Serves as a critical component in the development and calibration of mass spectrometry-based diagnostic kits for endocrine disorders.
• Forensic & Doping Control Analysis: Utilized in confirmatory testing protocols for the detection of endogenous steroids and their synthetic analogs in anti-doping laboratories.
• Biochemical Research: Applied in *in vitro* studies to understand the function and regulation of enzymes like 17α-hydroxylase and 21-hydroxylase.
• Quality Control & Method Validation: Essential for validating analytical methods, ensuring accuracy, precision, and compliance with regulatory guidelines (e.g., FDA, ICH) in pharmaceutical QC labs.

Basic Information

Product Name	17Alpha-Hydroxypregnenolone-21,21,21-D3
CAS No.	105078-92-0
Molecular Formula	C21H29D3O3
Molecular Weight	335.50 g/mol (approx.)
Synonyms	17α-Hydroxypregnenolone-d3; (3β)-3,17-Dihydroxypregn-5-en-20-one-21,21,21-d3; 17α-Hydroxy-5-pregnen-3β-ol-20-one-21,21,21-d3; Pregnenolone-17α-ol-21,21,21-d3; 17α-OH-Pregnenolone-d3; Deuterated 17α-Hydroxypregnenolone; 17α-Hydroxypregnenolone (21,21,21-D3); 17α-Hydroxypregnenolone-D3
EINECS	Contact for details

Quality Control

Every batch of 17Alpha-Hydroxypregnenolone-21,21,21-D3 is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to support its use as a reference material. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request and include data from NMR, HPLC, and MS to confirm identity, chemical purity, isotopic enrichment, and potency.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant and inert atmosphere to ensure stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.