Description

(R)-A-Methyl-1H-Indole-1-Acetic Acid is a high-purity chiral indole derivative, a crucial building block in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of enantiomerically pure pharmaceuticals and bioactive molecules. It is primarily needed by research institutions and pharmaceutical companies engaged in the synthesis of novel therapeutic agents, particularly in the areas of neurology and metabolic disorders.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), especially those targeting specific enantiomeric activity.
• Asymmetric Synthesis: Used as a starting material or intermediate in catalytic asymmetric reactions to construct complex molecular architectures.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies in drug discovery programs.
• Reference Standard: Employed as a high-purity analytical standard for method development and quality control in pharmaceutical analysis.
• Biochemical Research: Utilized in the study of enzyme-substrate interactions and other biochemical pathways where the indole moiety is relevant.

Basic Information

Product Name	(R)-A-Methyl-1H-Indole-1-Acetic Acid
CAS No.	105074-56-4
Molecular Formula	C11H11NO2
Molecular Weight	189.21 g/mol
Synonyms	(R)-1-Methylindole-3-acetic acid; (R)-Methyl 1H-indole-1-acetate (hydrolyzed form); (R)-Indole-1-acetic acid, α-methyl-; (R)-1H-Indole-1-acetic acid, α-methyl-; (R)-α-Methylindole-1-acetic acid; (R)-MIAA; (R)-Methyl IA; (R)-1-Methyl-1H-indole-3-acetic acid (tautomer)
EINECS	Contact for details

Quality Control

Our (R)-A-Methyl-1H-Indole-1-Acetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing identity, purity, and chiral excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storage under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.