Description

(R)-1-Oxo-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid is a high-purity chiral building block and key synthetic intermediate of significant importance in advanced organic synthesis. Its value lies in its role as a precursor for constructing complex molecules with specific stereochemistry, which is critical for biological activity. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), particularly for neurological and cardiovascular targets, as well as by fine chemical manufacturers producing specialized catalysts and ligands.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon in the research and development of novel drug candidates, especially for central nervous system (CNS) and cardiovascular diseases.
• Asymmetric Synthesis: Serves as a key starting material or intermediate in asymmetric catalytic reactions to produce enantiomerically pure compounds.
• Peptidomimetics Research: Used in the design and synthesis of peptidomimetics and constrained amino acid analogs for medicinal chemistry.
• Ligand and Catalyst Development: Employed in the preparation of specialized chiral ligands and organocatalysts for use in stereoselective transformations.
• Academic & Industrial R&D: Utilized in chemical research for methodological studies and the exploration of new synthetic pathways involving tetrahydroisoquinoline scaffolds.

Basic Information

Product Name	(R)-1-Oxo-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid
CAS No.	104974-47-2
Molecular Formula	C10H9NO3
Molecular Weight	191.18 g/mol
Synonyms	(R)-1,2,3,4-Tetrahydro-1-oxoisoquinoline-3-carboxylic Acid; (R)-Tetrahydroisoquinoline-3-carboxylic Acid-1-one; (3R)-1,2,3,4-Tetrahydro-1-oxo-3-isoquinolinecarboxylic Acid; (R)-1-Oxo-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic Acid; D-1,2,3,4-Tetrahydro-1-oxoisoquinoline-3-carboxylic Acid; (R)-Tic-OH-1-one; (R)-1-Oxo-Tic-OH
EINECS	Contact for details

Quality Control

Our (R)-1-Oxo-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting research and pharmaceutical-grade standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided to guarantee traceability and batch-to-batch consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee (R-isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.