Description

(3S)-3-Methyl-1,4-Benzodiazepine-2,5-Dione is a high-purity chiral benzodiazepine derivative, serving as a critical advanced pharmaceutical intermediate. Its defined stereochemistry at the 3-position is essential for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs) and for pharmacological research. This compound is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of novel therapeutic agents and complex organic synthesis.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of novel benzodiazepine-based active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and the development of new drug candidates targeting the central nervous system.
• Asymmetric Synthesis: Serves as a chiral template or starting material in stereoselective organic synthesis.
• Reference Standard: Employed as an analytical standard for quality control and method development in pharmaceutical analysis.
• Biochemical Research: Investigated for its interaction with biological receptors and enzymes in biochemical assays.

Basic Information

Product Name	(3S)-3-Methyl-1,4-Benzodiazepine-2,5-Dione
CAS No.	104873-98-5
Molecular Formula	C11H10N2O2
Molecular Weight	202.21 g/mol
Synonyms	(3S)-3-Methyl-1H-1,4-benzodiazepine-2,5(3H,4H)-dione; (S)-3-Methyl-1,4-benzodiazepine-2,5-dione; (S)-3-Methyl-2,5-dioxo-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine; (S)-3-Methyl-1,4-benzodiazepine-2,5(3H,4H)-dione; (S)-3-Methyl-1,4-benzodiazepine-2,5-dione; (3S)-3-Methyl-2,5-dioxo-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine
EINECS	Contact for details

Quality Control

Our (3S)-3-Methyl-1,4-Benzodiazepine-2,5-Dione is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) providing specifications for identity, purity, and chiral excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.