Description

Methyl-D3-Phosphonic Dichloride is a deuterated isotopologue of methylphosphonic dichloride, serving as a critical building block for the synthesis of isotopically labeled organophosphorus compounds. Its primary value lies in enabling advanced research and development in analytical chemistry, particularly for creating internal standards for mass spectrometry and for mechanistic studies in reaction pathways. This high-purity intermediate is essential for scientists and manufacturers in the pharmaceutical, agrochemical, and chemical research sectors who require precise deuterium labeling for metabolic studies, environmental analysis, and the development of novel materials.

Application

• Synthesis of Deuterated Chemical Warfare Agent Simulants for forensic analysis and environmental detection research.
• Preparation of Isotopically Labeled Internal Standards for accurate quantification in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS).
• Key Intermediate in Pharmaceutical Research for creating deuterated drug candidates to study pharmacokinetics and metabolic stability (Deuterium Kinetic Isotope Effect).
• Production of Labeled Agrochemicals for tracing environmental fate, metabolism in plants, and residue analysis studies.
• Material Science Research for incorporating deuterium labels into phosphonate-based polymers, ligands, or surface modifiers.
• NMR Spectroscopy Studies as a precursor for synthesizing probes that aid in complex structural elucidation.

Basic Information

Item	Details
Product Name	Methyl-D3-Phosphonic Dichloride
CAS No.	104801-17-4
Molecular Formula	CD3POCl2
Molecular Weight	150.93 g/mol
Synonyms	Deuterated Methylphosphonic Dichloride; (Trideuteriomethyl)phosphonic Dichloride; Methyl-d3-phosphonyl Dichloride; Phosphonic Dichloride, P-(Trideuteriomethyl)-; Methylphosphonic Dichloride-d3; CD3P(O)Cl2
EINECS	Contact for details

Quality Control

Every batch of Methyl-D3-Phosphonic Dichloride is produced and analyzed under strict quality protocols to ensure high isotopic and chemical purity suitable for sensitive research applications. Our quality assurance includes comprehensive analytical testing via NMR, GC-MS, and IR spectroscopy. A Certificate of Analysis (COA) detailing purity, isotopic enrichment (D-atom %), and impurity profile is provided with each shipment to guarantee traceability and compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic and moisture-sensitive nature, this material must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry, and well-ventilated place. Recommended long-term storage temperature is 2-8°C. Keep away from strong bases and moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Isotopic Purity (D-atom %)	≥ 99.0% (by 1H/2H NMR)
Water Content (KF)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.