Description

Methylphosphonic Acid (Methyl-D3, 98%) is a high-purity, isotopically labeled derivative of methylphosphonic acid, where the three hydrogen atoms of the methyl group are replaced by deuterium. This deuteration is critical for applications requiring precise molecular tracking, structural elucidation, and metabolic studies, offering enhanced analytical sensitivity and specificity. It is an essential building block and analytical standard for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, particularly in the development of deuterated active pharmaceutical ingredients (APIs) and specialized NMR spectroscopy.

Application

• Deuterated Pharmaceutical Intermediate: A key precursor in the synthesis of deuterium-labeled drugs, where the incorporation of deuterium can improve metabolic stability and pharmacokinetic profiles.
• NMR Spectroscopy & Analytical Standards: Serves as an internal standard or reference compound in Nuclear Magnetic Resonance (NMR) and Mass Spectrometry (MS) for quantitative analysis and method validation.
• Metabolic Pathway Research: Used as a tracer in metabolic studies to investigate biochemical pathways and drug metabolism mechanisms with high precision.
• Agrochemical Research: Employed in the development and analysis of novel, isotopically labeled pesticides and herbicides.
• Material Science: A specialized monomer or additive in the research of advanced polymers and materials where deuterium labeling is required for structural analysis.
• Forensic & Environmental Analysis: Acts as a high-purity standard for the detection and quantification of organophosphorus compounds in complex matrices.

Basic Information

Product Name	Methylphosphonic Acid (Methyl-D3, 98%)
CAS No.	104801-16-3
Molecular Formula	CD3PO3H2
Molecular Weight	116.04 g/mol
Synonyms	(Methyl-d3)phosphonic Acid; Deuterated Methylphosphonic Acid; Methylphosphonic-d3 Acid; Phosphonic Acid, P-(Methyl-d3)-; MPA-d3; Trisdeuteriomethylphosphonic Acid; [2H3]Methylphosphonic Acid
EINECS	Contact for details

Quality Control

Every batch of Methylphosphonic Acid (Methyl-D3, 98%) is produced and tested under strict quality management protocols to ensure identity, purity, and isotopic enrichment meet exacting standards. Our products undergo rigorous quality testing, including NMR and MS for deuterium incorporation verification and HPLC for chemical purity. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Deuterium Enrichment (MS)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.