Description

D-A H-Phosphonate is a specialized organophosphorus compound, a key chiral intermediate in modern synthetic chemistry. Its value lies in enabling the stereoselective synthesis of complex molecules, particularly in the development of nucleoside analogs and other biologically active compounds. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require precise control over molecular architecture.

Application

• Pharmaceutical Intermediate: Critical for the stereocontrolled synthesis of antiviral and anticancer nucleoside analogs.
• Agrochemical Synthesis: Used in the production of chiral pesticides and herbicides with enhanced activity and selectivity.
• Oligonucleotide & Peptide Chemistry: Serves as a building block for the preparation of modified oligonucleotides and phosphonopeptides.
• Catalyst & Ligand Preparation: Employed in the development of chiral catalysts and ligands for asymmetric synthesis.
• Academic & R&D: A valuable reagent for methodological development in organic and medicinal chemistry research.
• Fine Chemical Production: Used in the manufacture of specialty chemicals requiring specific phosphonate functionalities.

Basic Information

Product Name	D-A H-Phosphonate
CAS No.	104684-74-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	D-Alaninol H-Phosphonate; (R)-1-Amino-2-propanol Hydrogen Phosphonate; (R)-1-Amino-2-hydroxypropyl Phosphonate; D-1-Amino-2-propanol H-Phosphonic Acid; Alaninol, D-, H-phosphonate; Chiral Alaninol Phosphonate; Phosphonic acid, P-[(1R)-1-amino-2-hydroxypropyl]-
EINECS	Contact for details

Quality Control

Our D-A H-Phosphonate is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the exacting standards required for advanced synthetic applications. Certificates of Analysis (COA) documenting identity, purity, and chiral excess are available upon request, providing full traceability and compliance support for cGMP and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.