Description

Dl-Malic-2,3,3-D3 Acid is a deuterium-labeled isotopologue of DL-malic acid, a key dicarboxylic acid found in many biological systems. This compound is specifically engineered for use as an internal standard in mass spectrometry and NMR spectroscopy, providing enhanced analytical precision and accuracy. It is essential for researchers and manufacturers in pharmaceutical development, metabolic studies, and food science who require high-fidelity isotopic tracers for quantitative analysis.

Application

• Internal Standard for Mass Spectrometry (MS): Used for the precise quantification of malic acid and related metabolites in complex biological matrices.
• NMR Spectroscopy Tracer: Enables detailed metabolic pathway analysis and reaction mechanism studies due to its distinct deuterium signature.
• Pharmaceutical Research: Critical in drug metabolism and pharmacokinetics (DMPK) studies to track the fate of active pharmaceutical ingredients.
• Food & Beverage Analysis: Employed in authenticity testing and quality control to measure malic acid content in wines, juices, and other products.
• Biochemical Research: Serves as a labeled substrate or intermediate in enzymatic studies and metabolic flux analysis.
• Chemical Synthesis: Acts as a labeled building block for the synthesis of more complex deuterated compounds.

Basic Information

Product Name	Dl-Malic-2,3,3-D3 Acid
CAS No.	104596-63-6
Molecular Formula	C4H3D3O5
Molecular Weight	137.11 g/mol (approx.)
Synonyms	(2R*,3S*)-2,3,3-trideuterio-2-Hydroxybutanedioic Acid; DL-Hydroxybutanedioic-2,3,3-d3 Acid; (±)-Malic-2,3,3-d3 Acid; 2-Hydroxysuccinic-2,3,3-d3 Acid; Deuterated DL-Malic Acid; DL-Malic Acid-d3; Malic Acid (2,3,3-d3); Racemic Malic Acid-d3
EINECS	Contact for details

Quality Control

Our Dl-Malic-2,3,3-D3 Acid is produced under strict quality management protocols to ensure exceptional isotopic purity and chemical integrity. Each batch is characterized by advanced analytical techniques including NMR and LC-MS to confirm deuterium incorporation and chemical purity. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment, assay, and impurity profile is provided with every shipment, supporting compliance with rigorous research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed in a dry environment to prevent absorption of atmospheric moisture, which can affect stability and analytical performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (NMR/MS)	≥ 98 atom % D
Chemical Purity (Titration)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.