Description

7-Chloro-1-Phenyl-3,4-Dihydro-Isoquinoline is a high-purity, synthetically versatile heterocyclic compound that serves as a critical building block in advanced organic synthesis. Its unique fused-ring structure, featuring a chlorinated isoquinoline core, makes it an invaluable intermediate for pharmaceutical research and fine chemical manufacturing. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders, due to the privileged isoquinoline scaffold.
• Agrochemical Research: Used in developing novel active ingredients for crop protection agents, leveraging its halogenated aromatic system.
• Ligand and Catalyst Development: Serves as a backbone for creating specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Precursor: Employed in the synthesis of organic semiconductors, liquid crystals, and fluorescent dyes.
• Academic & Contract Research: Essential reagent for methodological studies in organic chemistry, including novel cyclization and functionalization reactions.
• Fine Chemical Synthesis: Building block for producing complex fragrance molecules, photographic chemicals, and other specialty compounds.

Basic Information

Product Name	7-Chloro-1-Phenyl-3,4-Dihydro-Isoquinoline
CAS No.	104576-30-9
Molecular Formula	C₁₅H₁₂ClN
Molecular Weight	241.72 g/mol
Synonyms	7-Chloro-1-phenyl-3,4-dihydroisoquinoline; 1-Phenyl-7-chloro-3,4-dihydroisoquinoline; 7-Chloro-1-phenyl-1,2,3,4-tetrahydroisoquinoline; 104576-30-9; 7-Chloro-1-phenyl-3,4-dihydro-2H-isoquinoline; 3,4-Dihydro-7-chloro-1-phenylisoquinoline; 7-Chloro-1-phenyl-3,4-dihydroisoquinoline (major); AI3-52302
EINECS	Contact for details

Quality Control

Every batch of 7-Chloro-1-Phenyl-3,4-Dihydro-Isoquinoline is manufactured under strict quality management systems. We employ advanced analytical techniques, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with each shipment. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.