Description

2-Amino-3-Cyano-4-Chloro-5-Formylthiophene is a high-value, multi-functional heterocyclic building block characterized by its reactive formyl and amino groups. This compound matters for its critical role as a versatile synthon in the synthesis of complex organic molecules, particularly in the development of advanced materials and active pharmaceutical ingredients (APIs). It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel thiophene-based scaffolds.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and kinase inhibitors.
• Agrochemical Synthesis: Building block for developing new generation herbicides, fungicides, and insecticides with thiophene cores.
• Organic Electronic Materials: Serves as a monomer or precursor for conjugated polymers and small molecules used in organic light-emitting diodes (OLEDs) and organic photovoltaics (OPVs).
• Dye and Pigment Manufacturing: Used in the synthesis of advanced colorants and fluorescent markers due to the electron-rich thiophene ring.
• Coordination Chemistry & Ligand Design: The amino and formyl groups allow for the creation of novel chelating ligands for metal catalysis and sensor development.
• Academic & Industrial Research: A valuable tool for exploring new heterocyclic chemistry and reaction methodologies in synthetic organic chemistry.

Basic Information

Product Name	2-Amino-3-Cyano-4-Chloro-5-Formylthiophene
CAS No.	104366-23-6
Molecular Formula	C6H3ClN2OS
Molecular Weight	186.62 g/mol
Synonyms	5-Formyl-2-amino-3-cyano-4-chlorothiophene; 4-Chloro-2-amino-3-cyano-5-thiophenecarboxaldehyde; 2-Amino-4-chloro-5-formyl-3-thiophenecarbonitrile; 4-Chloro-2-amino-5-formylthiophene-3-carbonitrile; ACCFT; Thiophene-5-carboxaldehyde, 2-amino-3-cyano-4-chloro-
EINECS	Contact for details

Quality Control

Our 2-Amino-3-Cyano-4-Chloro-5-Formylthiophene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.