Description

1H-Indole-5-Carbonitrile, 2-(Hydroxymethyl)- is a versatile indole-based nitrile derivative that serves as a critical building block in advanced organic synthesis. Its molecular structure, featuring both a hydroxymethyl and a nitrile functional group, makes it a valuable precursor for constructing complex heterocyclic systems and pharmacologically active molecules. This high-purity intermediate is essential for research and development chemists in the pharmaceutical, agrochemical, and material science industries seeking to develop new active ingredients and functional compounds.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, leveraging the indole scaffold's bioactivity.
• Material Science Research: Serves as a monomer or precursor for functional polymers and organic electronic materials due to its conjugated system.
• Chemical Biology Probes: Employed in the synthesis of fluorescent tags and molecular probes for studying biological processes.
• Academic & Contract Research: A valuable reagent for methodological development and exploratory chemistry in university and CRO laboratories.
• Fine Chemical Production: Integral to multi-step synthetic routes for producing specialty chemicals and complex natural product analogs.

Basic Information

Product Name	1H-Indole-5-Carbonitrile, 2-(Hydroxymethyl)-
CAS No.	104291-67-0
Molecular Formula	C10H8N2O
Molecular Weight	172.18 g/mol
Synonyms	2-(Hydroxymethyl)-1H-indole-5-carbonitrile; 2-Hydroxymethylindole-5-carbonitrile; 5-Cyano-2-hydroxymethylindole; (5-Cyano-1H-indol-2-yl)methanol; 1H-Indole-5-carbonitrile, 2-(hydroxymethyl)-; 2-Hydroxymethyl-1H-indole-5-carbonitrile
EINECS	Contact for details

Quality Control

Our 1H-Indole-5-Carbonitrile, 2-(Hydroxymethyl)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment, confirming compliance with customer specifications and industry best practices.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥97.0%
Purity (HPLC, Area %)	≥98.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.