Description

Diethyl 2-([3-(Bromomethyl)-2-Thienyl]Methylene)Malonate is a high-purity, specialized organic building block featuring a reactive bromomethyl group and a malonate ester moiety. This compound matters as a versatile synthon for constructing complex heterocyclic systems, particularly in the synthesis of advanced pharmaceutical intermediates and functional materials. It is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries who require precise molecular scaffolds for innovative product development.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of thiophene-containing active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Synthesis: Building block for creating novel herbicides, fungicides, and insecticides with thiophene backbones.
• Material Science Research: Used in the development of organic semiconductors, conductive polymers, and advanced organic frameworks (MOFs/COFs).
• Chemical Biology Probes: Serves as a starting material for synthesizing fluorescent tags or molecular probes targeting biological systems.
• Cross-Coupling Reactions: The bromomethyl group facilitates palladium-catalyzed cross-coupling (e.g., Suzuki, Heck) for carbon-carbon bond formation.
• Knoevenagel Condensation Substrate: The active methylene group is utilized in condensation reactions to form complex, conjugated systems.

Basic Information

Product Name	Diethyl 2-([3-(Bromomethyl)-2-Thienyl]Methylene)Malonate
CAS No.	104085-30-5
Molecular Formula	C13H15BrO4S
Molecular Weight	347.22 g/mol
Synonyms	Diethyl (3-Bromomethyl-2-thienylmethylene)malonate; 2-[(3-Bromomethyl-2-thienyl)methylene]malonic Acid Diethyl Ester; Diethyl 2-[(3-Bromomethyl-2-thienyl)methylene]propanedioate; Propanedioic acid, 2-[(3-(bromomethyl)-2-thienyl)methylene]-, 1,3-diethyl ester; (3-Bromomethyl-thiophen-2-ylmethylene)-malonic acid diethyl ester; Diethyl (3-bromomethylthiophen-2-ylmethylene)malonate; DBMM
EINECS	Contact for details

Quality Control

Our Diethyl 2-([3-(Bromomethyl)-2-Thienyl]Methylene)Malonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.