Description

Atipamezole Hydrochloride is a highly selective and potent α-2 adrenoceptor antagonist. This compound is of critical importance in veterinary medicine and pharmaceutical research for reversing the sedative and analgesic effects of α-2 adrenergic agonists. It is an essential pharmaceutical active ingredient primarily required by manufacturers of veterinary pharmaceuticals, research institutions, and contract development and manufacturing organizations (CDMOs).

Application

• Veterinary Pharmaceutical Formulations: Primary use as a reversal agent in injectable solutions to counteract sedation induced by drugs like medetomidine or dexmedetomidine in companion and large animals.
• Research & Development: A key reference standard and tool compound in pharmacological studies investigating the α-2 adrenergic system, receptor binding, and neurophysiology.
• Active Pharmaceutical Ingredient (API): Serves as the core active component in the manufacturing of finished veterinary medicinal products under Good Manufacturing Practice (GMP) conditions.
• Preclinical & Clinical Studies: Utilized in safety, efficacy, and toxicology studies for new drug applications and regulatory submissions.
• Chemical Synthesis Intermediate: Employed as a building block or precursor in the synthesis of more complex molecules or derivatives for specialized research.
• Diagnostic & Laboratory Use: Applied in in-vitro diagnostic assays and laboratory experiments to study autonomic nervous system responses.

Basic Information

Product Name	Atipamezole Hydrochloride
CAS No.	104075-48-1
Molecular Formula	C14H16N2·HCl
Molecular Weight	248.75 g/mol
Synonyms	Atipamezole HCl; 4-(2-Ethyl-2,3-dihydro-1H-inden-2-yl)-1H-imidazole Hydrochloride; MPV-1248; Antisedan (Veterinary Brand Name); α2-Adrenoceptor Antagonist; Atipamezolum Hydrochloridum; EUDRACODE 104075-48-1
EINECS	Contact for details

Quality Control

Our Atipamezole Hydrochloride is manufactured and tested to meet stringent quality standards suitable for pharmaceutical applications. We offer material compliant with current pharmacopeial monographs where applicable. Every batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, ensuring traceability and regulatory compliance for GMP-driven supply chains.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and potency.

Specification

Item	Specification
Appearance	White to almost white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.