Description

Atipamezole CAS NO 104054-27-5 is a potent and selective α-2 adrenoceptor antagonist. This compound is critically important for reversing the sedative and analgesic effects induced by α-2 adrenergic agonists in veterinary and research medicine. It is an essential pharmaceutical agent primarily needed by manufacturers of veterinary pharmaceuticals, contract research organizations (CROs), and academic institutions conducting neuropharmacological studies.

Application

• Veterinary Medicine: Primary use as a reversal agent for sedation induced by dexmedetomidine or medetomidine in companion animals and wildlife.
• Pharmaceutical Intermediates: Serves as a key active pharmaceutical ingredient (API) in the formulation of injectable veterinary reversal drugs.
• Research & Development: Utilized in preclinical and pharmacological research to study α-2 adrenergic receptor function and antagonist activity.
• Clinical Trials: Employed in veterinary clinical trials for safety and efficacy studies of anesthetic protocols.
• Chemical Synthesis: Used as a reference standard or building block in the synthesis of novel adrenergic compounds.
• Diagnostic Aid: Supports diagnostic procedures in veterinary practice by allowing rapid recovery from sedation for assessment.

Basic Information

Product Name	Atipamezole
CAS No.	104054-27-5
Molecular Formula	C14H16N2
Molecular Weight	212.29 g/mol
Synonyms	4-(2-Ethyl-2,3-dihydro-1H-inden-2-yl)-1H-imidazole; Atipamezole Hydrochloride; Antisedan; MPV-1248; L-659,066; ATI; α-2 Adrenoceptor Antagonist; Veterinary Reversal Agent
EINECS	Contact for details

Quality Control

Our Atipamezole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets high-grade pharmaceutical standards. Certificates of Analysis (COA) are provided, detailing specifications for assay, related substances, residual solvents, and other critical parameters. We support compliance with cGMP and relevant veterinary pharmacopoeial guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.