Description

(6R,23S,25S)-28-Deoxy-6,28-Epoxy-23-Hydroxy-25-(1-Methyl-1-Butenyl)Milbemycin B is a semi-synthetic derivative of the milbemycin family of 16-membered macrolides, known for its potent biological activity. This compound serves as a critical intermediate in the synthesis of advanced veterinary and agricultural acaricides and anthelmintics, offering high efficacy and specificity. It is essential for manufacturers and R&D facilities in the animal health and crop protection sectors seeking to develop next-generation parasitic control solutions.

Application

• Key Intermediate for the synthesis of high-potency milbemycin-based parasiticides.
• Veterinary Pharmaceutical R&D, particularly for developing novel endectocides against mites, ticks, and nematodes.
• Agrochemical Formulation as a precursor for advanced miticides and insecticides in crop protection.
• Biological Activity Research to study structure-activity relationships (SAR) within the milbemycin/avermectin class.
• Reference Standard for quality control and analytical method development in pharmaceutical manufacturing.
• Process Chemistry for scaling up production of related active pharmaceutical ingredients (APIs).

Basic Information

Product Name	(6R,23S,25S)-28-Deoxy-6,28-Epoxy-23-Hydroxy-25-(1-Methyl-1-Butenyl)Milbemycin B
CAS No.	103954-49-0
Molecular Formula	C₃₂H₄₆O₇
Molecular Weight	542.71 g/mol
Synonyms	28-Deoxy-6,28-epoxy-23-hydroxy-25-(1-methyl-1-butenyl)milbemycin B; 5-O-Demethyl-28-deoxy-6,28-epoxy-25-(1-methyl-1-butenyl)milbemycin B; LL-F28249-α-5-O-desmethyl-28-deoxy-6,28-epoxy-25-(1-methyl-1-butenyl); Milbemycin B derivative; 6,28-Epoxy-23-hydroxy-25-(1-methyl-1-butenyl)milbemycin B; Nemadectin intermediate; 103954-49-0
EINECS	Contact for details

Quality Control

Our production of (6R,23S,25S)-28-Deoxy-6,28-Epoxy-23-Hydroxy-25-(1-Methyl-1-Butenyl)Milbemycin B adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets precise customer specifications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment, supporting compliance in regulated pharmaceutical and agrochemical supply chains.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0% Any single impurity ≤ 2.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.