Description

[[3,5-Bis[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Phenyl]Methyl]Triphenylphosphonium Chloride is a highly specialized organosilicon-protected phosphonium salt reagent, primarily valued for its role as a key intermediate in complex organic synthesis. Its core value proposition lies in enabling precise, high-yield coupling reactions, particularly in the synthesis of sensitive or structurally intricate target molecules. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity building blocks for demanding synthetic routes.

Application

• Pharmaceutical Intermediate: A critical reagent in the multi-step synthesis of active pharmaceutical ingredients (APIs), especially for constructing complex aromatic or phenolic frameworks under mild conditions.
• Peptide & Nucleotide Chemistry: Used in protected monomer synthesis and fragment coupling where moisture-sensitive intermediates are involved.
• Advanced Material Synthesis: Serves as a precursor or catalyst component in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Agrochemical Research: Employed in the synthesis of novel herbicides, fungicides, and plant growth regulators that require specific, protected phenolic functionalities.
• Cross-Coupling Reactions: Functions as a stabilized Wittig reagent or ylide precursor for olefination reactions in fine chemical production.
• Academic & R&D Laboratories: A valuable tool for methodological development in organic chemistry, particularly for studies involving silicon-based protecting groups and phosphonium chemistry.

Basic Information

Product Name	[[3,5-Bis[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Phenyl]Methyl]Triphenylphosphonium Chloride
CAS No.	103929-86-8
Molecular Formula	C41H59ClO2PSi2
Molecular Weight	705.51 g/mol
Synonyms	[[3,5-Bis[(tert-Butyldimethylsilyl)oxy]phenyl]methyl]triphenylphosphonium chloride; (3,5-Bis-O-TBDMS-Benzyl)Triphenylphosphonium Chloride; TBDMS-Protected Phosphonium Salt; 3,5-Bis(TBDMSoxy)benzyltriphenylphosphonium chloride; Phosphonium salt, [[3,5-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl]methyl]triphenyl-, chloride; TBPPhCl (abbrev.)
EINECS	Contact for details

Quality Control

Every batch of [[3,5-Bis[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Phenyl]Methyl]Triphenylphosphonium Chloride is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including NMR, HPLC, and Karl Fischer titration, to ensure high purity and batch-to-batch consistency suitable for demanding synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the container for use to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.