Description

(S)-6,7-Dimethoxy-1,2,3,4-Tetrahydro-3-Isoquinolinecarboxylic Acid Hydrochloride is a high-purity chiral building block of significant importance in advanced pharmaceutical synthesis. Its value lies in its role as a key intermediate for the development of active pharmaceutical ingredients (APIs), particularly those targeting neurological and cardiovascular systems. This compound is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the synthesis of complex, stereospecific molecules.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the multi-step synthesis of novel drug candidates, especially alkaloid-derived therapeutics.
• API Development: Serves as a key building block for the research and production of Active Pharmaceutical Ingredients (APIs) requiring the (S)-enantiomer of the tetrahydroisoquinoline scaffold.
• Neurological Research: Used in the development of compounds for central nervous system (CNS) disorders, including potential treatments for Parkinson's disease and depression.
• Cardiovascular Drug Synthesis: Employed as an intermediate in the creation of molecules with potential antihypertensive or vasodilatory activity.
• Asymmetric Synthesis: Utilized in chiral pool synthesis and asymmetric transformations to construct complex molecular architectures with high enantiomeric purity.
• Chemical Reference Standard: Provides a high-purity standard for analytical method development, validation, and quality control in pharmaceutical laboratories.

Basic Information

Product Name	(S)-6,7-Dimethoxy-1,2,3,4-Tetrahydro-3-Isoquinolinecarboxylic Acid Hydrochloride
CAS No.	103733-66-0
Molecular Formula	C₁₂H₁₆ClNO₄
Molecular Weight	273.71 g/mol
Synonyms	(3S)-6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride; (S)-6,7-Dimethoxy-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid HCl; L-6,7-Dimethoxy-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid hydrochloride; (S)-Tic-OH.HCl (derived); (S)-6,7-Dimethoxy-Tic-OH.HCl; (S)-3-Carboxy-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-6,7-Dimethoxy-1,2,3,4-Tetrahydro-3-Isoquinolinecarboxylic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and cGMP intermediate use. A detailed Certificate of Analysis (COA) providing batch-specific data for identity, purity, and impurities is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Enantiomeric Excess)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.