Description

D-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid is a high-purity chiral non-proteinogenic amino acid derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its role as a versatile intermediate for constructing complex molecules with precise stereochemistry, which is essential for developing bioactive compounds. This product is primarily needed by research institutions and pharmaceutical companies engaged in the development of new drugs, peptide mimetics, and other fine chemicals where structural complexity and chiral purity are paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, including enzyme inhibitors and receptor modulators.
• Peptidomimetics Synthesis: Used to incorporate constrained, rigid amino acid analogs into peptide chains to enhance metabolic stability and bioavailability.
• Asymmetric Catalysis Research: Employed as a precursor or ligand in the development of new chiral catalysts for stereoselective reactions.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and protein interactions.
• Academic & Industrial R&D: Serves as a standard or starting material in methodological studies and process chemistry development within fine chemical laboratories.

Basic Information

Product Name	D-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid
CAS No.	103733-65-9
Molecular Formula	C10H11NO2
Molecular Weight	177.20 g/mol
Synonyms	(R)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid; D-Tic; D-Tetrahydroisoquinoline-3-carboxylic acid; (R)-Tic; (3R)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid; (R)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic Acid; D-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic Acid
EINECS	Contact for details

Quality Control

Our D-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chiral purity. Production adheres to cGMP guidelines where applicable, and each lot is supported by a comprehensive Certificate of Analysis (COA). The COA includes critical parameters such as chiral purity (HPLC), chemical purity, and residual solvent analysis, providing full traceability and compliance with research and pharmaceutical-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.