Description

L-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid Methyl Ester Hydrochloride is a high-purity chiral building block and synthetic intermediate of significant importance in advanced pharmaceutical research and development. Its core value lies in its role as a key precursor for synthesizing complex molecules, particularly those with potential biological activity in the central nervous system. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries working on novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of drug candidates targeting neurological disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and the development of novel bioactive compounds, particularly alkaloid analogs.
• Process Chemistry: Serves as a key starting material or intermediate in the scale-up and optimization of active pharmaceutical ingredient (API) manufacturing processes.
• Asymmetric Synthesis: Utilized in the construction of complex, enantiomerically pure molecules due to its defined stereochemistry.
• Chemical Reference Standard: Employed as an analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	L-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid Methyl Ester Hydrochloride
CAS No.	103733-33-1
Molecular Formula	C12H16ClNO2
Molecular Weight	241.71 g/mol
Synonyms	(3S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid methyl ester hydrochloride; L-TIQ-3-COOH-OMe·HCl; Methyl (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochloride; (S)-Methyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochloride; L-Tetrahydroisoquinoline-3-carboxylic acid methyl ester HCl; (S)-Tetrahydroisoquinoline-3-carboxylic acid methyl ester hydrochloride; Methyl L-1,2,3,4-tetrahydro-3-isoquinolinecarboxylate hydrochloride
EINECS	Contact for details

Quality Control

Our L-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid Methyl Ester Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.