Description

(S)-6,7-Dimethoxy-1,2,3,4-Tetrahydro-3-Isoquinoline Carboxylic Tert Butyl Ester is a high-purity chiral building block and key synthetic intermediate of significant value in advanced pharmaceutical research and development. Its defined stereochemistry and protected functional groups make it essential for constructing complex molecular architectures with high enantiomeric purity. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and fine chemical industries for applications in medicinal chemistry and active pharmaceutical ingredient (API) synthesis.

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the synthesis of biologically active compounds, particularly for central nervous system (CNS) targets and alkaloid-derived therapeutics.
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing libraries of novel drug candidates in hit-to-lead and lead optimization campaigns.
• Asymmetric Synthesis: Serves as a starting material or intermediate in stereoselective synthesis routes, leveraging its (S)-configured tetrahydroisoquinoline core.
• Process Chemistry Development: Employed in the scale-up and route scouting for the commercial manufacturing of complex APIs requiring this specific chiral moiety.
• Reference Standard: Used as an analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	(S)-6,7-Dimethoxy-1,2,3,4-Tetrahydro-3-Isoquinoline Carboxylic Tert Butyl Ester
CAS No.	103733-31-9
Molecular Formula	C16H23NO4
Molecular Weight	293.36 g/mol
Synonyms	(S)-6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid tert-butyl ester; (S)-Tert-butyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate; (S)-DTIQ-OtBu; (S)-1,2,3,4-Tetrahydro-6,7-dimethoxy-3-isoquinolinecarboxylic acid 1,1-dimethylethyl ester; (S)-BOC-DTIQ; (S)-3-((tert-Butoxycarbonyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
EINECS	Contact for details

Quality Control

Our (S)-6,7-Dimethoxy-1,2,3,4-Tetrahydro-3-Isoquinoline Carboxylic Tert Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) and standard purity assays, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee identity, purity, and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.