Description

(2R)-1-Acetyl-2,3-Dihydro-1H-Indole-2-Carboxylic Acid CAS NO 103476-80-8 is a high-purity, chiral indoline derivative that serves as a critical building block in advanced organic synthesis. Its value lies in its defined stereochemistry and functional groups, which enable the construction of complex molecules with precise three-dimensional architecture. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active pharmaceutical ingredients (APIs) and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of drug candidates targeting central nervous system (CNS) disorders, inflammation, and other therapeutic areas.
• Asymmetric Catalysis Research: Used as a ligand precursor or a model substrate in the development and study of new asymmetric synthetic methodologies.
• Agrochemical Development: Serves as a foundational structure for creating novel pesticides and herbicides with enhanced efficacy and selectivity.
• Chemical Biology & Proteomics: Employed in the design and synthesis of molecular probes and activity-based protein profiling (ABPP) reagents.
• Material Science: Potential precursor for specialty polymers and advanced organic materials requiring specific chiral motifs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds under cGMP guidelines.

Basic Information

Product Name	(2R)-1-Acetyl-2,3-Dihydro-1H-Indole-2-Carboxylic Acid
CAS No.	103476-80-8
Molecular Formula	C11H11NO3
Molecular Weight	205.21 g/mol
Synonyms	(R)-1-Acetylindoline-2-carboxylic acid; (2R)-1-Acetyl-2,3-dihydro-1H-indole-2-carboxylic acid; (R)-N-Acetyl-2-carboxyindoline; (R)-1-Acetyl-2-indolinecarboxylic Acid; (R)-2-Carboxy-1-acetylindoline; 1H-Indole-2-carboxylic acid, 1-acetyl-2,3-dihydro-, (2R)-; (R)-AIDA; (2R)-AIDC
EINECS	Contact for details

Quality Control

Our (2R)-1-Acetyl-2,3-Dihydro-1H-Indole-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support development with custom purity grades and specifications aligned with cGMP and ICH Q7 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.