Description

Tepoxalin is a non-steroidal anti-inflammatory drug (NSAID) belonging to the oxicam class, known for its dual inhibition of cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) pathways. This mechanism provides effective anti-inflammatory and analgesic properties, making it a valuable active pharmaceutical ingredient (API). It is primarily utilized in veterinary medicine for the management of pain and inflammation associated with osteoarthritis in dogs. Our supply of Tepoxalin CAS NO 103475-41-8 ensures high purity and reliable consistency for formulation development and commercial manufacturing.

Application

• Veterinary Pharmaceuticals: Primary use as an active ingredient in oral tablets for canine osteoarthritis.
• Analgesic Formulations: Development of medications for post-operative and chronic pain management in companion animals.
• Anti-inflammatory Drug Development: Serves as a key intermediate or reference standard in pharmaceutical R&D for novel NSAIDs.
• Veterinary Generic Drugs: Manufacturing of generic versions of approved veterinary medicinal products.
• Research Chemical: Used in biochemical and pharmacological studies investigating COX/LOX inhibition mechanisms.
• API Synthesis: Serves as a critical building block or final API in controlled synthesis processes for regulated markets.

Basic Information

Product Name	Tepoxalin
CAS No.	103475-41-8
Molecular Formula	C₁₇H₁₆N₂O₃
Molecular Weight	296.32 g/mol
Synonyms	Zubrin (trade name); 5-Ethyl-5-hydroxy-4-(4-methoxyphenyl)-2-phenyl-3,5-dihydro-2H-pyrrolo[3,2-d]pyridazin-7(6H)-one; 4-(4-Methoxyphenyl)-2-phenyl-5-ethyl-5-hydroxy-2H-pyrrolo[3,2-d]pyridazine-7(6H)-one; Tepoxaline; Tepoxalina; Tepoxalinum.
EINECS	Contact for details

Quality Control

Our Tepoxalin is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical use. Certificates of Analysis (COA) are provided, detailing parameters such as assay, related substances, residual solvents, and identification. We support compliance with ICH guidelines and relevant veterinary pharmacopoeial standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Any individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Water (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.