Description

(R)-2-(3,4-Dichloro-Phenyl)-Thiazolidine-4-Carboxylic Acid CAS NO 103261-10-5 is a high-purity chiral building block and intermediate of significant interest in advanced organic synthesis. Its value lies in its defined stereochemistry and functionalized thiazolidine core, which are critical for constructing complex molecules with specific biological activity. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, agrochemicals, and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and metabolic disorder targets.
• Agrochemical Synthesis: Used as a precursor in the design and synthesis of novel herbicides and fungicides, leveraging its halogenated aromatic moiety.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands or organocatalysts used in asymmetric synthesis to induce enantioselectivity.
• Peptidomimetic Research: The thiazolidine-4-carboxylic acid scaffold is valuable for creating conformationally constrained peptide analogs and protease inhibitors.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying enzyme mechanisms and biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring high stereochemical purity and reliable supply.

Basic Information

Product Name	(R)-2-(3,4-Dichloro-Phenyl)-Thiazolidine-4-Carboxylic Acid
CAS No.	103261-10-5
Molecular Formula	C10H9Cl2NO2S
Molecular Weight	278.15 g/mol
Synonyms	(R)-2-(3,4-Dichlorophenyl)thiazolidine-4-carboxylic acid; (4R)-2-(3,4-Dichlorophenyl)-1,3-thiazolidine-4-carboxylic acid; (R)-TDCA; (R)-DTCA; (R)-2-(3,4-DCP)thiazolidine-4-carboxylic acid; (R)-3,4-Dichloro-D-phenylalanine thiazolidine derivative; (R)-Enantiomer of 103261-10-5
EINECS	Contact for details

Quality Control

Our (R)-2-(3,4-Dichloro-Phenyl)-Thiazolidine-4-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting customer specifications and industry standards. Certificates of Analysis (COA) detailing identity, purity, and chiral excess are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (R-enantiomer)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.