Description

Pranlukast CAS NO 103177-37-3 is a potent and selective leukotriene receptor antagonist (LTRA) used as an active pharmaceutical ingredient (API). This compound is critical for the development and formulation of anti-asthmatic and anti-allergic medications, specifically targeting the cysteinyl leukotriene type 1 receptor. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the production of respiratory therapeutics and the study of inflammatory pathways. Our supply ensures high purity and consistent quality to meet stringent pharmacopeial standards for global drug development and manufacturing.

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription medications for the prophylaxis and chronic treatment of asthma.
• Anti-Allergic Formulations: Used in drugs designed to manage symptoms associated with allergic rhinitis and other hypersensitivity disorders.
• Clinical Research: Serves as a reference standard and key material in preclinical and clinical studies investigating leukotriene-mediated inflammatory diseases.
• Drug Development: Employed in the R&D of new therapeutic entities targeting the 5-lipoxygenase pathway for various inflammatory conditions.
• Generic Drug Manufacturing: Essential for companies producing generic versions of leukotriene receptor antagonist-based pharmaceuticals.
• Biochemical Research: Utilized as a tool compound in pharmacological assays and molecular biology research to study receptor antagonism.

Basic Information

Product Name	Pranlukast
CAS No.	103177-37-3
Molecular Formula	C27H23N5O4
Molecular Weight	481.50 g/mol
Synonyms	ONO-1078; SB 205312; Pranlukast Hydrate; 4-Oxo-8-[4-(4-phenylbutoxy)benzoylamino]-2-(tetrazol-5-yl)-4H-1-benzopyran hemihydrate; (+-)-4-Oxo-8-[p-(p-phenylbutoxy)benzamido]-2-(tetrazol-5-yl)-4H-1-benzopyran Hemihydrate; 1H-1-Benzopyran-4-one, 8-[[[4-(4-phenylbutoxy)phenyl]carbonyl]amino]-2-(1H-tetrazol-5-yl)-, hemihydrate
EINECS	Contact for details

Quality Control

Our Pranlukast is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for assay and related substances, residual solvent analysis, and identification by spectroscopic methods, to ensure compliance with pharmaceutical-grade specifications. We support our customers with full traceability and regulatory documentation. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and conformance to agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	NMT 1.0%
Related Substances (HPLC)	Total impurities: NMT 1.0% Any individual impurity: NMT 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	NMT 20 ppm
Sulfated Ash	NMT 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.