Description

1,2,3,4-Tetrahydro-Isoquinolin-5-Ol is a versatile heterocyclic building block of significant interest in advanced organic synthesis. Its core structure is a key pharmacophore, making it a critical intermediate for the development of novel active pharmaceutical ingredients (APIs). This compound is essential for research and production in the pharmaceutical, agrochemical, and fine chemical industries, where precise molecular construction is paramount.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of central nervous system (CNS) active compounds, including potential antidepressants, antipsychotics, and neuroprotective agents.
• Agrochemical Synthesis: Serves as a building block for developing new herbicides, fungicides, and plant growth regulators with specific biological activity.
• Fine Chemical Production: Used in the manufacture of complex dyes, pigments, and specialty chemicals requiring the tetrahydroisoquinoline scaffold.
• Academic & Contract Research: A valuable reagent for medicinal chemistry research, library synthesis, and exploring new chemical entities in drug discovery programs.
• Catalyst & Ligand Development: The nitrogen and oxygen functionalities make it a candidate for developing novel chiral ligands and organocatalysts for asymmetric synthesis.

Basic Information

Product Name	1,2,3,4-Tetrahydro-Isoquinolin-5-Ol
CAS No.	102877-50-9
Molecular Formula	C9H11NO
Molecular Weight	149.19 g/mol
Synonyms	5-Hydroxy-1,2,3,4-tetrahydroisoquinoline; 1,2,3,4-Tetrahydro-5-isoquinolinol; 5-Hydroxy-THIQ; THIQ-5-ol; Isoquinolin-5-ol, 1,2,3,4-tetrahydro-; 5-Hydroxy-1,2,3,4-tetrahydroisoquinoline; 102877-50-9
EINECS	Contact for details

Quality Control

Our 1,2,3,4-Tetrahydro-Isoquinolin-5-Ol is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent chemical identity. We provide detailed Certificates of Analysis (COA) with each shipment, confirming compliance with customer specifications and supporting cGMP requirements for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.