Description

(Tert.-Butyldimethylsilyloxy)Ethanol is a versatile organosilicon-protected alcohol intermediate, essential for advanced organic synthesis. Its primary value lies in its role as a key building block for introducing protected hydroxyl functionality into complex molecules, enabling multi-step synthetic sequences. This compound is critically needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of active pharmaceutical ingredients (APIs), fine chemicals, and novel materials.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of complex drug molecules and active pharmaceutical ingredients (APIs), particularly where selective hydroxyl group protection is required.
• Peptide & Nucleoside Synthesis: Used as a protecting group reagent for hydroxyl functions during the solid-phase or solution-phase synthesis of peptides, oligonucleotides, and their analogs.
• Agrochemical Development: Serves as an intermediate in the research and production of advanced herbicides, fungicides, and plant growth regulators.
• Material Science & Polymer Chemistry: Employed in the synthesis of functionalized monomers and precursors for specialty polymers, silicones, and surface-modifying agents.
• Cross-Coupling & Catalysis: Acts as a substrate or ligand precursor in palladium-catalyzed cross-coupling reactions and other metal-mediated transformations.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry and for creating novel chemical entities in discovery research.

Basic Information

Product Name	(Tert.-Butyldimethylsilyloxy)Ethanol
CAS No.	102229-10-7
Molecular Formula	C8H20O2Si
Molecular Weight	176.33 g/mol
Synonyms	2-[(tert-Butyldimethylsilyl)oxy]ethanol; 2-(tert-Butyldimethylsiloxy)ethanol; 2-Hydroxyethyl tert-butyldimethylsilyl ether; Ethanol, 2-[(1,1-dimethylethyl)dimethylsilyl]oxy]-; TBDMS-O-Ethanol; 2-TBDMSoxyethanol; 2-O-TBDMS-ethanol; 2-(Tert-butyldimethylsilyloxy)ethyl alcohol
EINECS	Contact for details

Quality Control

Our (Tert.-Butyldimethylsilyloxy)Ethanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatography (HPLC, GC) and spectroscopic methods (NMR, IR), to ensure high purity and consistency. Certificates of Analysis (COA) with detailed batch-specific results are provided to guarantee compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.